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There is compelling evidence that cognitive dysfunction is inherent to Parkinson’s disease (PD) (Aarsland et al. 2003; Aarsland et al. 2007a; Aarsland et al. 2010a). Clinical manifestations of cognitive deterioration in PD range from slight deficits -only demonstrable by means of comprehensive neuropsychological testing - up to dementia (Muslimovic et al. 2005; Aarsland et al. 2009; Foltynie et al. 2004). From the earliest stages of the disease, including drug-naà ¯ve subjects, patients suffering from PD may show cognitive impairment (CI). This can be restricted to a single domain or affects multiple cognitive domains (Muslimovic et al. 2005; Foltynie et al. 2004). Based on recent longitudinal studies, there is some evidence suggesting that, along the evolution of the disease, a subgroup of patients presenting defects on distinct cognitive domains will eventually deteriorate to the point of dementia associated to PD (PDD) (Aarsland et al. 2003; Buter et al. 2008; Hely et al. 2008; Emre et al. 2007). Starting on a similar theoretical approach than those used for MCI in Alzheimer’s disease (AD) -where early cognitive deterioration linearly progress to dementia- (Petersen et al. 2001a; Petersen et al. 2001b) an operative redefinition of the construct of MCI in PD has been proposed to identify and diagnose these initial cognitive deficits as early indicators of PDD (Caviness et al. 2007). Historically, MCI has been considered as the transitional stage between normality to dementia, based on the measurable presence of cognitive dysfunctions in single or multiple cognitive domains without concurring disabilities on activities of daily living (Petersen 2004). MCI in AD usually follows a linear progression from subtle deficits to dementia (... ...mild cognitive impairment to dementia in PD patients is characterized by the addition of cortical-type cognitive deficits atop a prominent and progressive frontal-striatal dysfunction. Besides the search for biomarkers, a usefulness definition and development of diagnostic criteria for PD-MCI, should consider to: (i) delimitate the heterogeneous cognitive deficit of PD and how we can accurately assess it in large sample of PD subjects; (ii) establish with prospective studies whether the prognostic value of the severity and the nature of the cognitive deficits; (iii) find a consensus of the minimum of cognitive tasks and instruments to assess cognition in PD and finally, (iv) delimitate the role played by common PD-related neuropsychiatric features such apathy or visual hallucinations as early markers of dementia in absence of evident neuropsychological impairment.

A Review of Dhoom III Essay

Saahlr (Aamlr Khan) Is a talented magician who runs an Indian circus in Chicago, once run by his magician father Iqbal Haroon Khan (Jackie Shroff), also using his unique skills to routinely rob a bank that he holds responsible for his father’s suicide many years ago. He must stay out of the reach of surly cop Jai Dikshit (Abhishek Bachchan) and his motor-mouth sidekick Ali (Uday Chopra), who have been dispatched to the Windy City of Chicago to crack the case. Resting to the belief about the two cracking the case to everyone’s delight, they are fancied with the best forces the Bank’s Chief Anderson (Andrew Bicknell) and the Chicago Police can offer. Here they meet Jai’s apprentice Victoria (Tabrett Bethell), who becomes their partner In crime and their swift support to resolve the case. The very typical Ali falls for the girl Ike he does for every girl he meets and scenes are somewhat directed to be comic, but fails big time. Amidst everything going hazy, nters Aaliya (Katrina Kalf) shown desperate enough to be considered In Saahlr’s troupe. She dances, sings, performs arial gymnastics, but acts. Despite being the lead actress as presented by the promotions, Katrina’s character has a very little to do in the story as most of the spaces she Is seen Is only utilized as dummy for navigating the story further. Aside from some genuinely cool moments like Aamir’s getaway on a Chicago waterfront or the climax staged on a dam, Dhoom 3 doesn’t offer very much by way of novelty or Inventiveness. What’s more. he film’s middle half gets weighed down by Saahir’s dreary revenge agenda, which is the sole motive behind the story and gets melodramatically derailed once a woman enters the fray.. The film Is missing the thrills that went hand-in-hand with the outrageous heists. screeching tires, and bad guy attitude associated with Dhoom. It’s hard to go into any more detail about the plot without giving away the film’s big twist, which reveals itself right before interval. To drive the story forward, Jal befriends Samar, the big twist and ricks him to get even with Saahir only to realize his poop, as he is countered by Saahir. The climax included long night chase In the Chicago downtown street to the Dam, where final scene takes place. In all this Dhoom franchise lacks the â€Å"Dhoom† factor that the audience might want to be entertained with and can be said to be an overload of chase, and of course Jai-All’s slapstick comedy and hammy acting. Though tne DacKgrouna music complements tne actlon sequences, songs I n a a ‘t nave tnelr job at place. Overall an average hindi action film without a bound plot.

Descartes s Argument On The Existence Of God - 1834 Words

In A Discourse on the Method, Descartes attempted to prove the existence of God in a priori manner. He did not trust his own senses when trying to prove the existence of God and therefore he relied on the ontological argument. By making the same assumption made by Anselm, which was that an ontological argument assumes that existence is a predicate of God, Descartes is able to conclude that ‘God exists’ is true by definition because the subject ‘God’, who already contains all perfections, already contains the predicate – exists, which is a perfection. Although this may be perceived as a strong claim to believers, many such as Gaunilo would have disagreed. Descartes postulates his argument in the fourth part of his Discourse in order to try and prove the existence of God. One must discuss why one feels Descartes attempted to do so and exactly how convincing his claim is. However, before one can understand his claim, it is important to grasp an idea of t he background that Descartes was writing from when he wrote the Discourse and the meaning of proof. Descartes was a physico-mathematician who dedicated a lot of his time to science. He realised that all truths tend to link to one another and therefore combining a fundamental truth with logic, would for him, lead to science. As a devoted Catholic, Descartes claimed that one of the main purposes of the Mediations was to defend Christian faith. In terms of proof, proof is evidence or an argument that establishes or helps toShow MoreRelatedDescartes Argument For God s Existence Of God Essay1103 Words   |  5 Pagespaper, I offer a reconstruction of Descartes argument for God’s existence in the Third Meditation. Descartes tries to prove the existence of God with an argument that proceeds from the clear and distinct idea of an infinite being to the existence of himself. He believes that his clear and distinct idea of an infinite being with infinite â€Å"objective reality† leads to the occurrence of the â€Å"Special Causal Principle†. I will start by discussing a nd analyzing Descartes clear and distinct idea of an infiniteRead MoreWilliam Robertson Smith, A Scottish Orientalist, Old Testament1692 Words   |  7 PagesThe god can no more exist without his people than the nation without its god. This quote means that the amount of belief that people have on God reflects on how much hope God has for a nation. This quote ties into various discussions that have been going on for a long time, and that is whether or not God exists. A well known philosopher who shares his view on this argument would be Rene Descartes who says, I think therefore I am. This assertion has come to be known as the cogito. Descartes struggledRead MoreEssay about Descartes First Meditation924 Words   |  4 PagesDescartes#8217; first meditation, his main objective is to present three skeptical arguments to bring doubt upon what he considers his basic beliefs. Descartes believes this to be an intricate part of his complete epistemological argument. Descartes skeptical arguments are not intended to be a denial of his basic beliefs. On the contrary, he uses these arguments to help prove one of his main theses, which is the existence of God. One of the main premises that Descartes uses in his proof forRead MoreThomas Aquinas vs. Descarates Essays673 Words   |  3 Pagesphilosophers Thomas Aquinas’s and Rene Descartes used the method of ontological argument for the existence of God and used intuition and reason alone to get to each other’s theory. Rene Descartes wrote out several mediations, but the one we’re going to touch base on is meditation III that he wrote in the 1600’s; While Thomas Aquinas’s wrote his five proofs of God in 1270 that specifies God’s existence in each proof; the one that gives the best argument is the existence of God in his III proof. While both philosophersRead MoreThe Argument On The Existence Of God1629 Words   |  7 PagesThe idea of God has been a part of man’s hist ory for centuries. Since time began there has been various combination of believers, and non-believers. Individuals who believes in God, belong to many different religion. Whereas, skeptics find the existence of God somewhat baffling, and have continually sought answers to His existence through scientific methods. As the world progresses in scientific, and technological advancement, the human race still faces the question of God’s existence. Many philosophersRead MoreDescartes Second Argument For The Existence Of God1642 Words   |  7 PagesPaper: Descartes’ Second Argument for the Existence of God As with almost all of Descartes inquiries the roots of his second argument for the existence of God begin with his desire to build a foundation of knowledge that he can clearly and distinctly perceive. At the beginning of the third meditation Descartes once again recollects the things that he knows with certainty. The problem arises when he attempts to clearly and distinctly understand truths of arithmetic and geometry. Descartes has enoughRead MoreDescartes Belief in God Essay1503 Words   |  7 PagesDescartes and God In his groundbreaking work, Meditations on First Philosophy, the French philosopher Rene Descartes lays the groundwork for many philosophical principles by attempting to â€Å"establish a bold and lasting knowledge† (171)1. The foundations for knowledge Descartes established would go on to influence a plethora of other philosophers and philosophical works. Descartes argues in his meditations first from the point of view of complete skepticism, using skepticism as a tool in order toRead MoreDescartes Theory Of Reasoning1184 Words   |  5 Pagesexplaining Antoine Arnauld’s objection to Descartes’ circular reasoning, I will be presenting a response given by Descartes. Then I will attempt to consider, on behalf of Arnauld, if the response is of adequacy, then I shall decide which view offers the best account. I suspect, however, that no matter what kind of response Descartes is to give, nothing will be able to save him from the torment of the so called ‘Cart esian circle’. In objection to Descartes’ reasoning behind his attempt to establishRead MoreThe On First Philosophy By Rene Descartes1699 Words   |  7 PagesMeditations on First Philosophy, published in 1641, Renà © Descartes sets out to establish a set of indubitable truths for the sciences. He begins by discarding all of his beliefs, then works to rebuild his beliefs based on careful thought. Descartes clearly states this goal, saying in the First Meditation, â€Å"I will work my way up†¦ I will accomplish this by putting aside everything that admits of the least doubt† (I, 17). He is able to establish his own existence, but struggles to move beyond his internal thoughtsRead MorePropelling Rational Thought Over Compelling Empiricism1459 Words   |  6 Pages In this paper I intend to examine the rationalist philosophy of Rene Descartes and fundamental empiricism of John Locke’s philosophical arguments, in particular their ideas relating to the science of man, his identity and attempt to explain distinctions between the two. As I lay the framework of my argument it is important to understand the precepts that serve as the underpinning for the views considered by Descartes and Locke respectively. Rationalism and empiricism are two modes of thought